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Substantially elevated serum glutamate and CSF GOT-1 levels associated with cerebral ischemia and poor neurological outcomes in subarachnoid hemorrhage patients


Silvia Snider, Luigi Albano, Filippo Gagliardi, Stefano Comai, Francesca Roncelli, Pierfrancesco De Domenico, Edoardo Pompeo, Pietro Panni, Nicole Bens, Maria Rosa Calvi, Pietro Mortini & Angela Ruban.

Scientific Reports 2023; 13:5246

Brain Illustration


Treatment with Pulsed Extremely Low Frequency Electromagnetic Field (PELF-EMF) Exhibit Anti-Inflammatory and Neuroprotective Effect in Compression Spinal Cord Injury Model

Goldshmit Yona, Shalom Moshe, Angela Ruban.

Special Issue Spinal Cord Injury: From Mechanisms to Nanotherapeutic Approache. Biomedicines 2022;10(2):325.

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Behavioral Aspects and Neurobiological Properties Underlying Medical Cannabis Treatment in Shank3 Mouse Model of Autism Spectrum Disorder

Shani Poleg, Emad Kיourieh, Angela Ruban, Guy Shapira, Noam Shomron, Boaz Barak and Daniel Offen 

Transl Psychiatry​ 2021 Oct 13;11(1):524.

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Blood glutamate scavengers increase pro-apoptotic signaling and reduce metastatic melanoma growth in-vivo

Goldshmit Y, Perelroizen R, Yakovchuk A, Banyas E, Mayo L, David S, Benbenishty A, Blinder P, Shalom M, Ruban A.
Sci Rep. 2021 Jul 19;11(1):14644.

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Quality of Life Res Differences in mental health and health-related quality of life between Israel and Italy public sample during COVID-19 quarantine. 

Amit-Aharon A, Dubovi I, Ruban A.  

Quality of Life Research Jan 14: 1–10, 2021.

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Knowledge and information credibility evaluation strategies regarding COVID-19: A cross-sectional study. 

Amit-Aharon A, Ruban A, Dubovi I. 

2021 January-February; 69(1): 22–31. 

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Liver enzymes and risk of stroke: The Atherosclerosis Risk in Communities Study (ARIC).

Ruban A, Daya N, Schneider ALC, Gottesman R, Selvin E, Coresh J, Lazo M, Koton S.
J Stroke. 2020 Sep;22(3):357-368.

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Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia.

Tsivion-Visbord H, Perets N, Sofer T, Bikovski L, Goldshmit Y, Ruban A, Offen D.
Transl Psychiatry. 2020 Sep 1;10(1):305.

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Blood glutamate scavengers and exercises as an effective neuroprotective treatment in mice with spinal cord injury. 

Goldshmit Y, Banyas E, Bens N, Yakovchuk A, Ruban A.

J. Neurosurg. Spine 3; 1-13, 2020.

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Blood Glutamate Scavenger as a Novel Neuroprotective Treatment in Spinal Cord Injury

Goldshmit Y, Jona G, Schmukler E, Solomon S, Pinkas-Kramarski R, Ruban A.
J Neurotrauma. 2018 Nov 1;35(21):2581-2590. 

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Onlay Bone Graft augmentation for the Treatment of Maxillary Atrophy: Implants long term follow-up (up to 131 months)

Devorah Schwartz-Arad, Ronen Ofec, Galit Eliyahu, Nir Sterer, Angela Ruban

J. Cosmetic Dentistry. 31(3); 76-93, 2015.

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Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment

Ruban A, Malina KC, Cooper I, Graubardt N, Babakin L, Jona G, Teichberg VI.Neurodegener Dis. 2015;15(4):233-42.

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MRS of Brain Metabolite Levels Demonstrates the Ability of Scavenging of Excess Brain Glutamate to Protect against Nerve Agent Induced Seizures

Ruban A, Biton IE, Markovich A, Mirelman D.
Int J Mol Sci. 2015 Feb 2;16(2):3226-36. 

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Long Term Follow-Up of Dental Implants Placed in Autologous Onlay Bone Graft.  

Devorah Schwartz-Arad, Ronen Ofec, Galit Eliyahu, Angela Ruban, Nir Sterer
Clin Implant Dent Rel Res. doi: 10.1111/cid.12288; 2014.

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Blood glutamate scavenging as a novel neuroprotective treatment for paraoxon intoxication

Ruban A, Mohar B, Jona G, Teichberg VI.
J Cereb Blood Flow Metab. 2014 Feb;34(2):221-7. 

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Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia

M Pérez-Mato,P Ramos-Cabrer, T Sobrino, M Blanco, A Ruban,D Mirelman, P Menendez, J Castillo, and F Campos.
Cell Death Dis. 2014 Jan; 5(1): e992.

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Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas

Ruban A, Berkutzki T, Cooper I, Mohar B, Teichberg VI.
Invest New Drugs. 2012 Dec;30(6):2226-35. 

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Normalization of GRK2 protein and mRNA measures in patients with depression predict response to antidepressants

Angela Matuzany-Ruban, Moran Golan, Nataly Miroshnik, Gabriel Schreiber, Sofia Avissar
Int J Neuropsychopharmacol​ 2010 Feb;13(1):83-91.

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Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion

Máté Marosi, János Fuzik, Dávid Nagy, Gabriella Rákos, Zsolt Kis, László Vécsei, József Toldi, Angela Ruban-Matuzani, Vivian I Teichberg, Tamás Farkas
Eur J Pharmacol​ 2009 Feb 14;604(1-3):51-7.

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The Contribution of the Blood Glutamate Scavenging Activity of Pyruvate to its Neuroprotective Properties in a Rat Model of Closed Head Injury

Alexander Zlotnik, Boris Gurevich, Evgenia Cherniavsky, Sergei Tkachov, Angela Matuzani-Ruban, Avner Leon, Yoram Shapira, Vivian I Teichberg
Neurochem Res 2008 Jun;33(6):1044-50.

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Phosducin-like protein levels in leukocytes of patients with major depression and in rat cortex: The effect of chronic treatment with antidepressants

Matuzany-Ruban A, Schreiber G, Farkash P, Avissar S.
Psychiatry Res. 2006 Mar 30;141(3):287-94.

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Dynamics of beta-arrestin1 protein and mRNA levels elevation by antidepressants in mononuclear leukocytes of patients with depression

A Matuzany-Ruban, S Avissar, G Schreiber.

J Affect Disord​ 2005 Nov;88(3):307-12.

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β-Arrestin-1 Levels: Reduced in Leukocytes of Patients With Depression and Elevated by Antidepressants in Rat Brain

Sofia Avissar , Angela Matuzany-Ruban, Keren Tzukert, Gabriel Schreiber

Am J Psychiatry​ 2004 Nov;161(11):2066-72.

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